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. 2018 Dec 27;56(8):5287–5303. doi: 10.1007/s12035-018-1443-8

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — a Sequence alignment of the C-terminal domain (residues 134–234) of ovine PrP compared with mule deer PrP. Note the four amino acid differences that where substituted giving rise to four mutants: ovine ARQ PrP (S98T), ovine ARQ PrP (S173N), ovine ARQ PrP (N177T), and ovine ARQ PrP (I208M). b Diagram of ovine PrP, and the locations of the native secondary structures in sheep ARQ PrP (134–234) are indicated: the α-helical regions are represented in blue and the β-sheet region in red. The diagram was generated using the program Swiss-PdbViewer (4.1.0)