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. 2019 Jul 2;10:567. doi: 10.3389/fgene.2019.00567

TABLE 3.

Issuance of PGX drugs over 7-year period (2011–2017) in Netherlands.

PGX Drugs Issuance (Thousand) % Therapeutic area
6-Mercaptopurine 136 0.04 oncology
Abacavir 116 0.03 infectious
Acenocoumarol 9,149 2.38 Cardiovascular
Allopurinol 6,210 1.62 other
Aripiprazole 1,625 0.42 psychiatry/neurology
Azathioprine 1,093 0.28 oncology
Capecitabine 297 0.08 oncology
Carbamazepine 3,033 0.79 psychiatry/neurology
Clopidogrel 10,195 2.65 Cardiovascular
Contraceptives with Estrogen 7,842 2.04 endocrinology
Efavirenz 145 0.04 infectious
Flecainide 1,806 0.47 Cardiovascular
Flucloxacillin 2,459 0.64 infectious
Fluorouracil 312 0.08 oncology
Haloperidol 2,678 0.70 psychiatry/neurology
Metoprolol 61,224 15.93 Cardiovascular
Proton Pump Inhibitors (PPI) 110,147 28.66 gastroenterology
Opioids 28,559 7.43 analgesic/anaesthesiology
Phenprocoumon 1,821 0.47 Cardiovascular
Phenytoin 1,028 0.27 psychiatry/neurology
Pimozide 599 0.16 psychiatry/neurology
Propafenone 97 0.03 Cardiovascular
SSRI 27,424 7.14 Psychiatry/neurology
Simvastatin and Atorvastatin 80,653 20.98 Cardiovascular
Tacrolimus 977 0.25 other
Tamoxifen 1,193 0.31 oncology
Tegafur 0.812 0.00 oncology
Thioguanine 53 0.01 oncology
Tricyclic antidepressants 15,034 3.91 psychiatry/neurology
Venlafaxine 7,698 2.00 Psychiatry/neurology
Voriconazole 24 0.01 Infectious
Zuclopenthixol 722 0.19 psychiatry/neurology
Total PGX drugs issued 384,351
Total prescribed drugs (PGX and non-PGX drugs) 1,600,241
% of PGX drugs among all medications 24.02%