Table 1.
Clinical characteristics of participants in our study.
| Variablesa | Discovery set | Validation set | Combined set | ||||||
|---|---|---|---|---|---|---|---|---|---|
| TC (N = 152) | Controls (N = 151) | Pa | TC (N = 250) | Controls (N = 255) | Pa | TC (N = 402) | Controls (N = 406) | Pa | |
| Age, years | 53.0 ± 8.3 | 51.5 ± 8.9 | 0.136 | 52.2 ± 7.5 | 51.7 ± 8.8 | 0.425 | 52.5 ± 7.8 | 51.6 ± 8.8 | 0.117 |
| Female, n (%) | 95 (62.5) | 88 (58.3) | 0.452 | 153 (61.2) | 161 (63.1) | 0.654 | 248 (61.7) | 249 (61.3) | 0.916 |
| Smoking, n (%) | 41 (27.0) | 51 (33.8) | 0.198 | 64 (25.6) | 78 (30.6) | 0.213 | 105 (28.1) | 129 (31.8) | 0.076 |
| Alcohol drinking, n (%) | 38 (25.0) | 52 (34.4) | 0.072 | 66 (26.4) | 59 (23.1) | 0.396 | 104 (25.9) | 111 (27.3) | 0.637 |
| History of DM, n (%) | 53 (34.9) | 33 (21.9) | 0.012 | 91 (36.4) | 59 (23.1) | 0.001 | 144 (35.8) | 92 (22.7) | < 0.001 |
| BMI, kg/m2 | 25.2 ± 3.6 | 24.4 ± 2.2 | 0.028 | 25.1 ± 3.5 | 24.4 ± 2.5 | 0.016 | 25.1 ± 3.5 | 24.4 ± 2.4 | 0.001 |
| TC subtypes, n (%) | |||||||||
| PTC | 117 (77.0) | 193 (77.2) | 310 (77.1) | ||||||
| FTC | 25 (16.4) | 47 (18.8) | 72 (17.9) | ||||||
| MTC | 10 (6.6) | 2 (0.8) | 12 (3.0) | ||||||
| PDTC and ATC | 0 (0) | 8 (3.2) | 8 (2.0) | ||||||
PTC, papillary thyroid carcinoma; FTC, follicular thyroid cancer; MTC, medullary thyroid carcinoma; PDTC, poorly differentiated thyroid carcinoma; ATC, anaplastic thyroid carcinoma.
a
Continuous variables were expressed as mean ± SD, and compared by the Student's t-test. Categorical variables were expressed as frequency counts, and compared by the Pearson χ2 test.