Table 2.
Associations of leukocyte mtDNA-CN with TC risk in discovery, validation, and their combined sets.
| Variables | Cases, N | Controls, N | Without adjustment | With adjustmenta | ||
|---|---|---|---|---|---|---|
| OR (95%CI) | p | OR (95%CI) | p | |||
| DISCOVERY STAGE | ||||||
| Each 1-SD increase | 152 | 151 | 1.45 (1.14–1.84) | 0.002 | 1.48 (1.15–1.91) | 0.002 |
| REPLICATION STAGE | ||||||
| Each 1-SD increase | 250 | 255 | 1.44 (1.20–1.72) | <0.001 | 1.42 (1.18–1.71) | <0.001 |
| COMBINED COHORT | ||||||
| Each 1-SD increase | 402 | 406 | 1.44 (1.25–1.66) | <0.001 | 1.43 (1.23–1.66) | <0.001 |
| BY TERTILES IN CONTROLS | ||||||
| T1 (≤ −0.93) | 93 (23.1) | 138 (34.0) | Reference | Reference | ||
| T2 (−0.93–0.30) | 118 (29.4) | 135 (33.2) | 1.30 (0.90–1.86) | 0.158 | 1.28 (0.89–1.86) | 0.183 |
| T3 (>0.30) | 191 (47.5) | 133 (32.8) | 2.13 (1.51–3.01) | <0.001 | 2.10 (1.48–3.00) | <0.001 |
| P trend | <0.001 | <0.001 | ||||
a
Adjusted for age, sex, BMI, smoking habit, alcohol drinking habit, and history of DM.