Table 3.
Associations of leukocyte mtDNA-CN with subtypes of TC risk in the combined sets.
| mtDNA-CN | Control | PTC | FTC | MTC | PDTC and ATC | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR (95%CI)a | Pa | N (%) | OR (95%CI)a | Pa | OR (95%CI)a | Pa | OR (95%CI)a | Pa | |
| Each 1-SD increase | 406 | 310 | 1.43 (1.22–1.68) | <0.001 | 72 | 1.66 (1.26–2.18) | <0.001 | 1.54 (0.47–5.02) | 0.477 | 1.10 (0.25–4.81) | 0.903 |
| BY TERTILES IN CONTROLS | |||||||||||
| T1 (≤ −0.93) | 138 (34.0) | 72 (23.3) | Reference | 14 (19.4) | Reference | Reference | Reference | ||||
| T2 (−0.93–0.30) | 135 (33.2) | 92 (29.7) | 1.29 (0.86–1.91) | 0.215 | 21 (29.2) | 1.54 (0.74–3.20) | 0.252 | 0.45 (0.08–2.42) | 0.352 | 1.48 (0.24–9.10) | 0.672 |
| T3 (>0.30) | 133 (32.8) | 146 (47.1) | 2.09 (1.43–3.06) | <0.001 | 37 (51.4) | 2.79 (1.41–5.51) | 0.003 | 1.11 (0.30–4.04) | 0.878 | 1.53 (0.25–9.53) | 0.647 |
| p trend | <0.001 | 0.008 | 0.558 | 0.885 | |||||||
a
Adjusted for age, sex, BMI, smoking habit, alcohol drinking habit, and history of DM. The main purpose of the bold values is to more differentially present the data above and below the bold line.