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. 2019 Jul 2;10:1500. doi: 10.3389/fimmu.2019.01500

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Copyright © 2019 Lu, Arranz-Trullén, Prats-Ejarque, Pulido, Bhakta and Boix.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNase3 and RNase3-H15A induce autophagy in control and M. aurum infected macrophages. Mouse macrophages were uninfected or infected with M. aurum and treated with 10 μM of protein (RNase3, RNase3-H15A) or 100 nM Rapamycin for 24 h. Real-time qPCR measured the relative expression of (A) BECN1 and (B) ATG5 genes normalized by the housekeeping gene β-actin. Results are shown from 3 independent experiments (mean ± SD); (C) Immunoblot of LC3-processing and the housekeeping GAPDH control. Results are shown from 3 independent experiments (mean ± SD). *Statistically significant differences compared with the control sample are indicated (p-value < 0.05).