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. 2019 Jul 8;9:9852. doi: 10.1038/s41598-019-46293-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Benchmark results obtained from the safety scores. (a) Putative targets are sorted from unsafe to safer according to each safety assessment method. The sorted lists are then trimmed on the 50^th percentile and compared with a set of targets with known issues in order to obtain the normalized ppv-curves. The dashed line in black indicates the normalized ppv for a random ordering of target-disease pairs. (b) Three-set Venn diagram showing the number of targets covered the different safety scoring systems.