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. 2019 Jul 8;4:24. doi: 10.1038/s41541-019-0121-9

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

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Fig. 2 — Effect of chemical conjugation on the immunogenicity of Pfs230. a Anti-Pfs230 antibody titer of Pfs230, Pfs230-EPA, and Pfs230-OMPC-1 in mice immunized twice (on days 0 and 28) with 2.5 µg antigen dose per mouse. ELISA was performed using sera obtained on day 42 using Pfs230 as plate antigen. b SMFA results showing the number of oocysts developed in each of the mosquitos fed on P. falciparum gametocytes mixed with immune sera obtained from mice immunized with Pfs230, Pfs230-EPA and Pfs230-OMPC-1 along with mosquitos fed on naïve mouse sera as control. SMFA was carried out using pooled sera for each group (10 mice in each group) after 1–5 dilution of sera. c Table listing the % reduction in oocyst count in mosquitos fed on immune sera compared to control sera for each group along with the antibody titer of the sera used as well as the prevalence data (% of mosquitos with at least one oocyst). Mice were immunized with conjugates formulated with AdjuPhos^®. Error bars represent 95% confidence limit of the geometric mean. Statistical differences between groups were measured using a Kruskal–Wallis One-way ANOVA followed by a Dunn multiple comparator test. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001