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. 2019 Jul 8;4:24. doi: 10.1038/s41541-019-0121-9

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effect of antigen dose on anti-Pfs230 antibody titer of mice immunized with Pfs230 conjugates of OMPC and EPA. a Anti-Pfs230 antibody titer observed in sera of mice vaccinated with 3 different Pfs230-OMPC conjugates and different doses. b Serum antibody titer observed in sera of mice vaccinated with 3 different doses of Pfs230-EPA conjugate. Mice were immunized on days 0 and 28 with conjugates at stated doses formulated in AdjuPhos^® and sera collected on day 42 were analyzed by ELISA. c Table showing the functional activity, obtained by SMFA, of OMPC and EPA conjugates at various doses in terms of TRA (% reduction in oocyst count compared to control) and prevalence (% of dissected mosquitos with at least one oocyst in the midgut). Table also shows the antibody titer of the sera, which were diluted 1 to 5-fold for SMFA. Error bars represent 95% confidence limit of the geometric mean. Statistical differences between groups were measured using a Kruskal–Wallis one-way ANOVA followed by a Dunn multiple comparator test. *p ≤ 0.05