Table 1.
Characteristics and synthetic parameters of Pfs230-OMPC conjugates
| Conjugate | Lot # | Conjugation Chemistry | # Maleimide or thiols per antigen | # thiols or maleimide per OMPC | Antigen input (mg) | OMPC input (mg) | Thiol/Maleimide (input ratio) | Antigen Load (wt.%) | Antigens/OMPC (#) |
|---|---|---|---|---|---|---|---|---|---|
| Pfs230-OMPC-1 | 8151 | Method 1 | 0.28 (mal) | 3640 (thiol) | 7.62 | 7.03 | 6.7 (0.52) | 6 | 109 |
| Pfs230-OMPC-2 | 8132 | Method 1 | 0.78 (mal) | 1730 (thiol) | 0.4 | 2.2 | 6.7 (0.15) | 9.5 | 173 |
| Pfs230-OMPC-3 | 8169 | Method 1 | 2.55 (mal) | 2200 (thiol) | 10.1 | 21.4 | 1.0 (0.32) | 12 | 218 |
| Pfs230-OMPC-4 | 8167 | Method 1 | 1.69 (mal) | 3465 (thiol) | 18.3 | 16.2 | 1.0 (0.53) | 17 | 310 |
| Pfs230-OMPC-5 | 8133 | Method 2 | 2.8 (thiol) | 736 (mal) | 1.16 | 4.5 | 2.1 (0.20) | 12.5 | 228 |