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. 2019 Jul 8;9:9831. doi: 10.1038/s41598-019-46409-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ECG analysis. Representative ECGs showing (a) a normal ECG in sinus rhythm, (b) a premature ventricular contraction (PVC), (c) a couplet, (d) a non-sustained ventricular tachycardia (nsVT) and (e) a sustained VT (susVT). Scale bars represent 250 ms. (f,g) Time course of average arrhythmic events per day (left panels) and total amount of ventricular arrhythmias (right panels) following cryo-injury (f, day 3–day 6) and following implantation of hEHTs (g, day 10–day 35). Data are visualized using median ± interquartile range. Grey zones indicate postoperative period recordings (48 h) following induction of MI and graft implantation which were excluded from analysis. Statistical differences between both groups were calculated using a mixed effects linear regression for longitudinal data with animals as cluster variable and the day by group interaction if significant; else both main effects (left panels). Potential differences for total amount of arrhythmias were compared using negative binominal regression with the groups as predictor (right panels). (h) Fraction of control and hEHT animals in which the different subtypes of ventricular arrhythmias could be detected following hEHT implantation (day 10–day 35). The occurrence of any arrhythmic event was analyzed using mixed effects logistic regression with animals as cluster variable and the interaction between types of arrhythmic events and group if significant; else both main effects. (i) Incidence of arrhythmias by subclass following hEHT implantation (day 10–day 35). Data are visualized using individual data points and median ± interquartile range. Potential differences were calculated using mixed effects negative binominal regression with animals as cluster variable and the interaction between types of arrythmias and group if significant; else both main effects. Ctrl, animals implanted with cell-free fibrin constructs (n = 8); hEHT, animals with implanted hEHTs (n = 10).