Table 1.

Percentage of Bcl-2 protein positive cells in prostate cancer, as determined by immunohistology in different studies.

		Gleason			Metastases
Bcl-2 proteins		2–4	5–7	8–10	Bone	Lymph node	Total	BH3 mimetics (inhibition)
Anti-apoptotic	Bcl-2	20–25	14–42	33–41	13–65	14–38	24–70
	Bcl-xl	100	100	100	100	100	100
	Mcl-1	70	71	94	75	100	81
Pro-apoptotic	Bax	100	100	100	100	100	95–100
	Bak	nd	nd	nd	nd	nd	78–100

BH3 mimetics for inhibition of the anti-apoptotic proteins. nd, not determined.