Table 2.
Drugs interactions of NBP and FLC against C. albicans in vitro.
| Straina | MIC80(μg/ml)b | FICIb | Interpretationc | |||
|---|---|---|---|---|---|---|
| Alone | Combined | |||||
| NBP | FLC | NBPcomb | FLCcomb | |||
| CA4 | 128 | 0.5 | 8 | 0.25 | 0.56 | NI |
| CA8 | 128 | 1 | 64 | 0.5 | 1 | NI |
| CA10 | 128 | >512 | 32 | 0.25 | 0.25 | SYN |
| CA16 | 128 | >512 | 32 | 1 | 0.25 | SYN |
| CA103 | 128 | >512 | 32 | 0.25 | 0.25 | SYN |
| CA632 | 128 | >512 | 32 | 0.25 | 0.25 | SYN |
a
CA, Candida albicans.
b
NBP, n-butylphthalide; FLC, fluconazole; FICI, fractional inhibitory concentration index.
c
SYN, synergism; NI, no interaction.
MIC80 denotes minimum inhibitory concentration of drug that inhibited fungal growth by 80% compared with the growth control.
MIC80 values and FICIs are shown as the median of three independent experiments.