Table 2.
Gene coexpression modules from the RA inflamed synovium that are associated with anti-TNF response at the transcriptomic level.
| Gene coexpression modulea | Gene | Module significance | Intramodular connectivity (m ± sd) | P-value |
|---|---|---|---|---|
| GCM-1 | 21 | 0.91 | 4.03 ± 1.27 | 0.00021 |
| GCM-2 | 61 | 0.81 | 8.73 ± 2.84 | 0.0048 |
| GCM-3 | 52 | 0.87 | 7.45 ± 3.05 | 0.0076 |
| GCM-4 | 22 | 0.86 | 4.6 ± 1.39 | 0.0077 |
| GCM-5 | 143 | 0.86 | 10.99 ± 4.68 | 0.014 |
| GCM-6 | 27 | 0.66 | 3.79 ± 1.66 | 0.019 |
| GCM-7 | 18 | 0.68 | 3.17 ± 0.91 | 0.028 |
| GCM-8 | 119 | 0.77 | 10.11 ± 4.16 | 0.033 |
| GCM-9 | 18 | 0.79 | 3.55 ± 0.95 | 0.033 |
| GCM-10 | 87 | 0.78 | 9.43 ± 3.97 | 0.036 |
| GCM-11 | 32 | 0.78 | 3.76 ± 1.4 | 0.037 |
| GCM-12 | 70 | 0.74 | 7.22 ± 2.63 | 0.038 |
| GCM-13 | 24 | 0.69 | 3.24 ± 1.01 | 0.046 |
GCM, gene coexpression module; IMC, intramodular connectivity; M, mean; MS, module significance; SD, standard deviation.
a
Gene coexpression modules showing a significant association (P < 0.05) with the anti-TNF response when comparing EULAR good responders (N = 5 biopsies from the RNA inflamed tissues) and EULAR non-responders (N = 3 biopsies from the RNA inflamed tissues) at the transcriptomic level.