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. 2019 Jul 8;10(7):520. doi: 10.1038/s41419-019-1749-0

Fig. 8. CTRP3 exerted its protective role on pathological cardiac hypertrophy through inhibiting p38/CREB/ER stress pathway.

Fig. 8

a Representative western blot (left) and quantification (right) of the ER stress signaling pathway activity in NRCMs from the indicated groups (n = 4 samples per group). b Representative western blot (left) and quantification (right) of the p38-CREB and ER stress signaling pathway activity in NRCMs from the indicated groups (n = 4 samples per group). c Representative western blot (left) and quantification (right) of ER stress and p38-CREB signaling pathway activity, protein expression levels of ANP and β-MHC in NRCMs from the indicated groups (n = 4 samples per group). *p < 0.05, **p < 0.01 between indicated groups. In the bar graphs, the data are presented as the mean ± SEM. d Proposed protective mechanism of the role of CTRP3 in pathological cardiac hypertrophy. CTRP3 inhibits the activation of the p38/CREB signaling pathway and ER stress pathway in cardiomyocytes under pressure overload, thereby alleviating pathological cardiac hypertrophy