. 2019 Jul 8;9:9857. doi: 10.1038/s41598-019-46291-9

Table 3.

Grading of brain histopathology.

	Treatment Group	Grading score for brain lesion per mouse (0 to +++)								Most frequent observed severity (average severity)
	Treatment Group	m1	m2	m3	m4	m5	m6	m7	m8	Most frequent observed severity (average severity)
Nonsuppurative encephalitis	Ctl	++	++	++	++	+++	+++	+++	N/A	++ (2.43)
Nonsuppurative encephalitis	50 mg/kg	0	0	0	0	0	+	+	+	0 (0.38)
Gliosis	Ctl	+	++	++	++	++	++	+++	N/A	++ (2.00)
Gliosis	50 mg/kg	0	0	0	0	+	+	+	+	0/+ (0.50)
Nonsuppurative meningitis	Ctl	+	++	++	++	++	++	++	N/A	++ (1.86)
Nonsuppurative meningitis	50 mg/kg	0	0	0	0	0	0	0	+	0 (0.13)
Neural necrosis	Ctl	+	+	+	+	++	++	++	N/A	+ (1.43)
Neural necrosis	50 mg/kg	0	0	0	0	0	+	+	+	0 (0.38)
Malacia	Ctl	0	0	+	+	+	+	+	N/A	+ (0.71)
Malacia	50 mg/kg	0	0	0	0	0	0	0	+	0 (0.13)
Hemorrhage	Ctl	0	0	0	0	0	+	+	N/A	0 (0)
Hemorrhage	50 mg/kg	0	0	0	0	0	0	0	0	0 (0)