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. 2019 Jul 8;9:9822. doi: 10.1038/s41598-019-46371-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Analysis of the distribution of informative, and uninformative (background contaminant and carryover) features in the plasma data set. (B) Representative intensity profiles in blanks and post-blank samples of UPLC-MS features labelled as informative, column carry over and contaminants; (C) PC1 vs PC2 scores (top) and loadings (bottom) from the PCA of UPLC-MS profiles obtained from the analysis of blanks, using features labelled as carryover or contaminant.