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CPUY192018 relieved the LPS-induced inflammatory conditions in the kidney. (A–E) The levels of serum IL-18, IL-1β, IL-6, TNF-α and NO activity. The results are expressed as the means ± SEM (n = 8, in each group). *p < 0.05, **p < 0.01 and ***p < 0.001, one-way ANOVA with Tukey–Kramer posttest. (F) Immunohistochemical detection of p65, p-p65 and IL-1β protein levels in the kidney sections from mice. The bars indicate the magnification (20 μm).
