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. 2019 Jul 8;39(7):BSR20190304. doi: 10.1042/BSR20190304

Figure 2. GYY4137 reverses hypoxia induced dysfunction in cell proliferation, cell migration, generation of ROS in PASMCs.

Figure 2

(A) Increased OD450 value in CCK-8 assay of PASMCs with hypoxia compared with cells cultured under standard condition, and ((B) Scale bars, 100 μm) representative images of EdU assay. PASMCs under hypoxia showed significant narrow width of scratch in scratch test assay ((C,D), Scale bars, 100 μm), increased cell number in lower chamber in Transwell assay (E,F, original magnification ×200), and ROS generation (G,H, original magnification ×200), while treatment of DHA inhibited hypoxia-induced increase in cell migration. The data are presented as the mean ± standard error of mean (S.E.M), one-way ANOVA, followed by Tukey’s post-hoc test; *P<0.05, vs normoxia group; #P<0.05, vs hypoxia group.