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. 2019 Jun 15;11(6):3825–3840.

Figure 1.

Figure 1

LXRα agonist T0901317 inhibits AS plaques and foam cell formation. Eight-month old male Apoe-/- mice were treated with a high-fat diet in the presence and absence of an LXRα agonist (T0901317) or antagonist (GSK2033) for 3 months. HE staining showed that T0901317 significantly decrease the plaque area at the left ventricular outflow tract of Apoe-/- mice contrast to normal chow diet (ApoE-/-) or high fat diet (Model) (A), Oil red O staining showed that there were fewer Oil Red O-stained foam cells in the AS plaque in T0901317-treated mice (B), lastly, transmission electron microscopy technology was used to confirm that fewer foam cells were found in T0901317 treated Apoe-/- high fat diet mice than in other groups (C). #P < 0.05 vs. model. Scale bar, 20 μm or 5 μm.