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. 2019 Jun 15;11(6):3825–3840.

Figure 3.

Figure 3

LXRα agonist promotes the expression of LXRα, ABCA1 and ABCG1 in macrophages in AS plaque. In order to find out the cause of the reduction of foam cells and AS plaque area, we firstly confirm T0901317 can promote the expression of LXRα, then the RCT protein (ABCA1 and ABCG1), IDL was used to detect the expression of LXRα in CD68 positive macrophages, the yellow area of LXRα and CD68 double positive staining is indicated by the arrows, as shown, T0901317 stimulated more LXRα expression in macrophages (A), and the IDL assay also indicate that T0901317 promote more ABCA1 (B) and ABCG1 (C) expression in macrophages. Scale bar, 10 μm.