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. 2019 Jun 15;11(6):3850–3861.

Figure 5.

Figure 5

P16 deletion could reduce apoptosis. A. Representative micrographs of paraffin-embedded renal sections stained with TUNEL. Values are mean ± SEM of six determinations per group. B. Percentage of cells positive for TUNEL relative to total cells. *P < 0.05 compared with WT mice at the same time after ATN; ##P < 0.01, ###P < 0.001 compared with control at the same genotyped mice; &P < 0.05, &&P < 0.01, &&&P < 0.001 compared with ATN-24 h group at the same genotyped mice; @P < 0.05 compared with ATN-48 h at the same genotyped mice. C. Western blots of renal extracts showing p53, Bcl-2, Bax and cleaved caspase3, and β-actin was the loading control. D-G. Protein levels relative to β-actin were assessed by densitometric analysis. Values are mean ± SEM of six determinations per group. *P < 0.05, **P < 0.01, ***P < 0.001 compared with WT mice at the same time after ATN; #P < 0.05, ##P < 0.01, ###P < 0.001 compared with control at the same genotyped mice; &P < 0.05, &&P < 0.01, &&&P < 0.001 compared with ATN-24 h group at the same genotyped mice; @P < 0.05, @@P < 0.01 compared with ATN-48 h at the same genotyped mice.