Table 1.
Associations between IL-4 and IL-6 polymorphisms and gastric cancer risk
| Genotype | Cases, n (%) | Controls, n (%) | OR (95% CI) | AOR (95% CI)a | p-value |
|---|---|---|---|---|---|
| IL-4 rs2243248 | |||||
| TT | 421 (87.89) | 420 (86.96) | Reference | Reference | |
| GT | 57 (11.90) | 62 (12.84) | 0.92 (0.63, 1.35) | 0.92 (0.63, 1.37) | 0.693 |
| GG | 1 (0.21) | 1 (0.21) | 1.00 (0.06, 16.04) | 0.74 (0.05, 12.11) | 0.836 |
| GT/GG | 58 (12.11) | 63 (13.04) | 0.92 (0.63, 1.35) | 0.92 (0.63, 1.35) | 0.671 |
| Additive model | 0.92 (0.64, 1.34) | 0.92 (0.63, 1.34) | 0.660 | ||
| IL-4 rs2070874 | |||||
| TT | 309 (64.51) | 321 (66.46) | Reference | Reference | |
| TC | 147 (30.69) | 142 (29.40) | 1.08 (0.81, 1.42) | 1.03 (0.78, 1.37) | 0.817 |
| CC | 23 (4.80) | 20 (4.14) | 1.19 (0.64, 2.22) | 1.24 (0.66, 2.32) | 0.511 |
| TC/CC | 170 (35.49) | 162 (33.54) | 1.09 (0.84, 1.42) | 1.06 (0.81, 1.39) | 0.685 |
| Additive model | 1.08 (0.87, 1.35) | 1.07 (0.85, 1.34) | 0.576 | ||
| IL-4R rs2057768 | |||||
| TT | 125 (26.10) | 139 (28.78) | Reference | Reference | |
| CT | 241 (50.31) | 239 (49.48) | 1.12 (0.83, 1.51) | 1.16 (0.86, 1.58) | 0.331 |
| CC | 113 (23.59) | 105 (21.74) | 1.20 (0.84, 1.71) | 1.17 (0.81, 1.69) | 0.405 |
| CT/CC | 354 (73.90) | 344 (71.22) | 1.14 (0.86, 1.52) | 1.17 (0.87, 1.56) | 0.298 |
| Additive model | 1.10 (0.92, 1.31) | 1.09 (0.91, 1.31) | 0.349 | ||
| IL-4R rs2107356 | |||||
| CC | 192 (40.08) | 202 (41.82) | Reference | Reference | |
| TC | 224 (46.76) | 215 (44.51) | 1.10 (0.84, 1.44) | 1.15 (0.87, 1.51) | 0.340 |
| TT | 63 (13.15) | 66 (13.66) | 1.00 (0.68, 1.50) | 0.98 (0.65, 1.46) | 0.908 |
| TC/TT | 287 (59.92) | 281 (58.18) | 1.08 (0.83, 1.39) | 1.09 (0.84, 1.42) | 0.500 |
| Additive model | 1.03 (0.85, 1.24) | 1.02 (0.85, 1.23) | 0.813 | ||
| IL-4R rs1805015 | |||||
| TT | 402 (83.92) | 404 (83.64) | Reference | Reference | |
| CT | 76 (15.87) | 76 (15.73) | 1.01 (0.71, 1.42) | 1.00 (0.70, 1.42) | 0.994 |
| CC | 1 (0.21) | 3 (0.62) | 0.34 (0.04, 3.24) | 0.34 (0.04, 3.29) | 0.351 |
| CT/CC | 77 (16.08) | 79 (16.36) | 0.98 (0.70, 1.38) | 0.97 (0.69, 1.38) | 0.880 |
| Additive model | 0.96 (0.69, 1.33) | 0.95 (0.68, 1.33) | 0.754 | ||
| IL-4R rs1801275 | |||||
| AA | 326 (68.06) | 329 (68.12) | Reference | Reference | |
| GA | 137 (28.60) | 133 (27.54) | 1.04 (0.78, 1.38) | 1.04 (0.78, 1.38) | 0.812 |
| GG | 16 (3.34) | 21 (4.35) | 0.77 (0.39, 1.50) | 0.71 (0.36, 1.41) | 0.331 |
| GA/GG | 153 (31.94) | 154 (31.88) | 1.00 (0.77, 1.32) | 0.99 (0.75, 1.30) | 0.934 |
| Additive model | 0.97 (0.77, 1.22) | 0.95 (0.75, 1.20) | 0.662 | ||
| IL-6 rs6949149 | |||||
| TT | 151 (31.52) | 144 (29.81) | Reference | Reference | |
| GT | 228 (47.60) | 248 (51.35) | 0.88 (0.66, 1.17) | 0.89 (0.66, 1.19) | 0.421 |
| GG | 100 (20.88) | 91 (18.84) | 1.05 (0.73, 1.51) | 1.06 (0.73, 1.54) | 0.758 |
| GT/GG | 328 (68.48) | 339 (70.19) | 0.92 (0.70, 1.21) | 0.93 (0.70, 1.23) | 0.610 |
| Additive model | 1.01 (0.84, 1.21) | 1.02 (0.85, 1.22) | 0.863 | ||
| IL-6 rs10499563 | |||||
| TT | 298 (62.21) | 303 (62.73) | Reference | Reference | |
| TC | 163 (34.03) | 157 (32.51) | 1.06 (0.81, 1.39) | 1.08 (0.82, 1.42) | 0.602 |
| CC | 18 (3.76) | 23 (4.76) | 0.80 (0.42, 1.51) | 0.84 (0.44, 1.60) | 0.601 |
| TC/CC | 181 (37.79) | 180 (37.27) | 1.02 (0.79, 1.33) | 1.05 (0.80, 1.36) | 0.747 |
| Additive model | 0.99 (0.79, 1.23) | 1.01 (0.81, 1.26) | 0.948 | ||
| IL-6 rs1800796 | |||||
| CC | 226 (47.18) | 268 (55.49) | Reference | Reference | |
| CG | 203 (42.38) | 187 (38.72) | 1.29 (0.99, 1.68) | 1.28 (0.98, 1.68) | 0.071 |
| GG | 50 (10.44) | 28 (5.80) | 2.12 (1.29, 3.48) | 2.20 (1.33, 3.63) | 0.002 |
| GC/GG | 253 (52.82) | 215 (44.51) | 1.40 (1.08, 1.80) | 1.41 (1.09, 1.82) | 0.009 |
| Additive model | 1.38 (1.13, 1.68) | 1.39 (1.14, 1.71) | 0.001 | ||
| IL-6R rs2228145 | |||||
| AA | 163 (34.03) | 157 (32.51) | Reference | Reference | |
| CA | 232 (48.43) | 235 (48.65) | 0.95 (0.72, 1.26) | 0.96 (0.72, 1.29) | 0.803 |
| CC | 84 (17.54) | 91 (18.84) | 0.89 (0.62, 1.29) | 0.88 (0.61, 1.29) | 0.519 |
| CA/CC | 316 (65.97) | 326 (67.49) | 0.93 (0.71, 1.22) | 0.94 (0.72, 1.24) | 0.678 |
| Additive model | 0.94 (0.79, 1.13) | 0.94 (0.79, 1.13) | 0.541 |
a
Adjusted for age, gender, smoking, drinking, and H. pylori infection status.
p-values <0.05 are shown in bold. AOR, adjusted odds ratio; OR, odds ratio.