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. 2019 Jun 15;11(6):3461–3471.

Figure 4.

Figure 4

NEDD4 overexpression abrogates diosgenin-induced anti-tumor activity. A: The MTT assay was used to measure the growth of PC-3 cells after diosgenin exposure in combination with NEDD4 cDNA transfection. B: Cell apoptosis was detected with Annexin V-FITC/PI staining and flow cytometry in PC-3 cells after diosgenin exposure in combination with NEDD4 cDNA transfection. C: A wound healing assay was used to measure the migration of PC-3 cells after diosgenin exposure in combination with NEDD4 cDNA transfection. D: A Transwell chamber invasion assay was used to detect PC-3 cell invasiveness after diosgenin exposure in combination with NEDD4 cDNA transfection. *P < 0.05, when compared to the control group; #P < 0.05, when compared to diosgenin exposure alone or NEDD4 cDNA transfection alone.