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HAb18IgG eliminated CSCs via CD44s-STAT3 signaling. (A, B) CD44s, pSTAT3 and STAT3 protein levels (A) or relative STAT3 transcriptional activity (B) in MIA PaCa-2 and PANC-1 cells treated with 10 µg/ml HAb18IgG(H18) or nIgG for 2 days. (C-E) ALDH+ subpopulation ratios (C, D) or number of spheres (E) in MIA PaCa-2 and PANC-1 cells treated with HAb18IgG alone or in combination with STAT3 inhibitor WP1066 (5 µM).
