Table 2.
List of the most significant SNPs associated with low VO2max
| S. No | RS id | CHR | BP | MA | MAF | CHISQ | P | OR (L95-U95) | Gene | AA | CCF | HWpval |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | rs10037485 | 5 | 156770133 | A | 0.6053 | 16.75 | 4.26E-05 | 12.78 (3.27-49.92) | CYFIP2 and FNDC9 | T | 0.605, 0.107 | 1 |
| 2 | rs75380747 | 12 | 7188562 | A | 0.1053 | 16.59 | 4.65E-05 | 0.09 (0.02-0.32) | C1R | G | 0.895, 0.429 | 0.365 |
| 3 | rs13695 | 17 | 38545193 | A | 0.05263 | 15.56 | 8.01E-05 | 0.06 (0.01-0.32) | TOP2A | C | 0.947, 0.536 | 1 |
| 4 | rs7726099 | 5 | 79521704 | G | 0.2105 | 14.61 | 0.0001323 | 0.13 (0.04-0.38) | SERINC5 | A | 0.789, 0.321 | 1 |
| 5 | rs45074 | 5 | 126993249 | C | 0.6842 | 14.25 | 0.0001598 | 7.94 (2.56-24.66) | CTXN3 and CTC-548H10.2 | C | 0.684, 0.214 | 0.002 |
| 6 | rs743346 | 21 | 47851636 | A | 0.02778 | 13.78 | 0.0002056 | 0.04 (0.01-0.37) | PCNT | G | 0.972, 0.607 | 0.003 |
| 7 | rs4959505 | 6 | 8869571 | A | 0.6316 | 13.43 | 0.0002475 | 7.89 (2.45-25.42) | A | 0.632, 0.179 | 1 | |
| 8 | rs2462603 | 7 | 145813854 | A | 0.1944 | 13.3 | 0.0002648 | 0.13 (0.04-0.42) | CNTNAP2 | G | 0.806, 0.357 | 0.859 |
| 9 | rs11726022 | 4 | 188170467 | A | 0.2632 | 13.23 | 0.0002751 | 0.14 (0.05-0.43) | G | 0.737, 0.286 | 1 | |
| 10 | rs9835332 | 3 | 56667682 | C | 0.6053 | 12.02 | 0.0005274 | 7.05 (2.2-22.62) | FAM208A | G | 0.605, 0.179 | 1 |
| 11 | rs11033800 | 11 | 4790948 | A | 0.1111 | 11.78 | 0.0005977 | 0.13 (0.03-0.45) | CPA5 | C | 0.889, 0.500 | 0.345 |
| 12 | rs17854248 | 7 | 130007388 | A | 0.1111 | 11.78 | 0.0005977 | 0.13 (0.03-0.45) | MMP26 and OR51F1 | G | 0.889, 0.500 | 0.345 |
| 13 | rs4675801 | 2 | 242493511 | G | 0.6316 | 11.32 | 0.0007657 | 6.29 (2.06-19.22) | BOK-AS1 | C | 0.632, 0.214 | 0.98 |
| 14 | rs7178698 | 15 | 94945719 | C | 0.02941 | 11.3 | 0.0007748 | 0.05 (0.01-0.46) | MCTP2 | T | 0.971, 0.643 | 0.321 |
| 15 | rs978979 | 3 | 56533016 | A | 0.2632 | 11.29 | 0.0007776 | 0.17 (0.06-0.49) | G | 0.737, 0.321 | 0.297 | |
| 16 | rs4657537 | 1 | 166268048 | G | 0.2632 | 11.29 | 0.0007776 | 0.17 (0.06-0.49) | A | 0.737, 0.321 | 1 | |
| 17 | rs1263811 | 14 | 21993498 | G | 0.4118 | 10.95 | 0.0009359 | 17.5 (2.12-144.7) | SALL2 | G | 0.412, 0.038 | 1 |
| 18 | rs55989856 | 22 | 39493294 | G | 0.02632 | 10.92 | 0.0009507 | 0.06 (0.01-0.48) | APOBEC3H | T | 0.974, 0.679 | 1 |
| 19 | rs7258236 | 19 | 6760974 | G | 0.1053 | 10.87 | 0.0009793 | 0.14 (0.04-0.49) | SH2D3A | T | 0.895, 0.536 | 0.126 |
CHR: Chromosome; SNP ID: Single nucleotide polymorphism ID; BP: Base pair position at the respective chromosome as per GRCh37.p13; MA: Minor allele name; MAF: Frequency of minor allele in controls; ChisQ: Basic allelic test chi-square; P: p-value; OR: Odd ratio; SE: Standard error; L95: Lower bound of 95% confidence interval for odds ratio; U95: Upper bound of 95% confidence interval for odds ratio. AA: Associated Allele; CCF: Case, Control Frequencies; HWpval: p-value of Hardy-Weinberg equilibrium.