Table III.

miRNA candidates targeting the mTOR gene predicted by bioinformatics analysis.

					Database algorithm
miRNA ID	Proposed target gene	Ensembl gene ID	miRNA sequence		Diana	miRWalk	TargetScan	PicTar	miRDB
hsa-miR-581	mTOR	ENSG00000198793	UCUUGUGUUCUCUAGAUCAGU	Score	0.95	–	–	3.42	63
				P-value	0.04	0.014	–	–	Rank 20
				Binding	8mer	8mer	–	–	7mer
				Region	UTR3	UTR3	–	UTR3	UTR3
hsa-miR-96-5p	mTOR	ENSG00000198793	UUUGGCACUAGCACAUUUUUGCU	Score	0.85	–	95	–	60
				P-value	0.04	–	0.79	–	Rank 24
				Binding	7mer	–	7mer-m8	–	7mer
				Region	UTR3	–	UTR3	–	UTR3
hsa-miR-767-3pa	mTOR	ENSG00000198793	UCUGCUCAUACCCCAUGGUUUCU	Score	0.99	–	–	–	88
				P-value	0.004	0.001	–	–	Rank 4
				Binding	6mer	10mer	–	–	7mer
				Region	UTR3	UTR3	–	–	UTR3
hsa-miR-1185-3p	mTOR	ENSG00000198793	AUAUACAGGGGGAGACUCUUAU	Score	0.88	–	–	–	65
				P-value	0.04	–	–	–	Rank 15
				Binding	8mer	–	–	–	7mer
				Region	UTR3	–	–	–	UTR3
hsa-miR-1271-5p	mTOR	ENSG00000198793	CUUGGCACCUAGCAAGCACUCA	Score	0.84	–	95	–	61
				P-value	0.03	–	0.79	–	Rank 22
				Binding	7mer	–	7mer	–	7mer
				Region	UTR3	–	UTR3	–	UTR3
hsa-miR-496	mTOR	ENSG00000198793	UGAGUAUUACAUGGCCAAUCUC	Score	0.86	–	–	–	72
				P-value	0.03	0.014	–	–	Rank 9
				Binding	8mer	8mer	–	–	7mer
				Region	UTR3	UTR3	–	–	UTR3
hsa-miR-335-3p	mTOR	ENSG00000198793	UUUUUCAUUAUUGCUCCUGACC	Score	0.85	–	–	–	67
				P-value	0.03	0.014	–	–	Rank 13
				Binding	8mer	8mer	–	–	7mer
				Region	UTR3	UTR3	–	–	UTR3
hsa-miR-3182	mTOR	ENSG00000198793	GCUUCUGUAGUGUAGUC	Score	0.85	–	–	–	79
				P-value	0.028	–	–	–	Rank 6
				Binding	7mer	–	–	–	7mer
				Region	UTR3	–	–	–	UTR3

miRNA, microRNA; miR, microRNA; UTR3, 3 untranslated region; mTOR, mammalian target of rapamycin.