Table IV.

miRNA candidates targeting the RPTOR gene predicted by bioinformatics analysis.

					Database algorithm
miRNA ID	Proposed target gene	Ensembl gene ID	miRNA sequence		Diana	miRWalk	TargetScan	PicTar	miRDB
hsa-miR-340-3p	RPTOR	ENSG00000141564	UCCGUCUCAGUUACUUUAUAGC	Score	0.79	–	–	–	63
				P-value	0.03	0.008	–	–	Rank 9
				Binding	9mer	9mer	–	–	9mer
				Region	UTR3	UTR3	–	–	UTR3
hsa-miR-548o-3p	RPTOR	ENSG00000141564	CCAAAACUGCAGUUACUUUUGC	Score	0.71	–	–	–	–
				P-value	0.002	0.008	–	–	–
				Binding	9mer	9mer	–	–	–
				Region	UTR3	UTR3	–	–	–
hsa-miR-3121-3p	RPTOR	ENSG00000141564	UAAAUAGAGUAGGCAAAGGACA	Score	0.997	–	–	–	64
				P-value	0.10	–	–	–	Rank 6
				Binding	8mer	–	–	–	7mer
				Region	UTR3	–	–	–	UTR3
hsa-miR-4802-3p	RPTOR	ENSG00000141564	UACAUGGAUGGAAACCUUCAAGC	Score	0.83	–	–	–	66
				P-value	0.04	–	–	–	Rank 4
				Binding	8mer	–	–	–	7mer
				Region	UTR3	–	–	–	UTR3
hsa-miR-2114-3p	RPTOR	ENSG00000141564	CGAGCCUCAAGCAAGGGACUU	Score	0.73	–	–	–	67
				P-value	0.02	–	–	–	Rank 3
				Binding	8mer	–	–	–	7mer
				Region	UTR3	–	–	–	UTR3
hsa-miR-3183	RPTOR	ENSG00000141564	GCCUCUCUCGGAGUCGCUCGGA	Score	0.71	–	–	–	77
				P-value	0.003	–	–	–	Rank 1
				Binding	7mer	–	–	–	7mer
				Region	UTR3	–	–	–	UTR3
hsa-miR-654-5p	RPTOR	ENSG00000141564	UGGUGGGCCGCAGAACAUGUGC	Score	–	–	–	–	59
				P-value	–	0.008	–	–	Rank 13
				Binding	–	9mer	–	–	7mer
				Region	–	UTR3	–	–	UTR3

miRNA, microRNA; miR, microRNA; UTR3, 3 untranslated region; RPTOR, regulatory-associated protein of mTOR complex I.