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. 2019 Jun 24;18(2):1938–1948. doi: 10.3892/ol.2019.10521

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Copyright: © Shaji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Only significant module found by MCODE analysis with cut-off criteria of MCODE score >3 and node >4. This module consists of 8 nodes (BCL-2, CCND1, FOS, HRAS, JUN, NFKB1, PIK3CA and VEGFA) and 27 edges, and VEGF is the seed gene in this module with an MCODE score of 6. MCODE, Molecular Complex Detection; CCND1, cyclin D1; FOS, Fos proto-oncogene, AP-1 transcription factor subunit; HRAS, HRas proto-oncogene, GTPase; NFKB1, nuclear factor κB subunit 1; PIK3CA, phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit α; VEGFA, vascular endothelial growth factor A.