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. 2019 Jun 24;18(2):1938–1948. doi: 10.3892/ol.2019.10521

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Copyright: © Shaji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Pathway Map of Glioblastoma obtained from Wikipathways using Cytoscape. Targets genes of deregulated miRNAs are highlighted with thick borders. Five targets of downregulated miRNAs; CCND1, IGF1R, PIK3CA, HRAS and MET, found to play an important role in GBM signaling cascades. miRNAs, microRNAs; CCND1, cyclin D1; IGF1R, insulin like growth factor 1 receptor; PIK3CA, phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit α; HRAS, HRas proto-oncogene, GTPase; MET, MET proto-oncogene, receptor tyrosine kinase.