(A) TMZ reduced the protein expression of CTGF in myocardial tissue from diabetic rats. (B) Effects of TMZ on the protein expression of SOD-2 and on MDA content in myocardial tissue in each group. Values are expressed as the mean ± standard deviation (n=8 animals/group). *P<0.05, **P<0.01 and ***P<0.01 vs. N; #P<0.05 vs. C. C, vehicle-treated diabetic group; CFs, cardiac fibroblasts; CTGF, connective tissue growth factor; MDA, malondialdehyde; N, normal group; TMZ, trimetazidine; SOD, superoxide dismutase.