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. 2019 Jul 1;10:659. doi: 10.3389/fphar.2019.00659

Figure 6.

Figure 6

H&E stained histopathological analysis of knee joints. Histopathological images of H&E stained knee joints taken at low (100×) and high (400×) magnification showing: (A) NC animal representing articular cartilage (Ac), synovial membrane (Sm), spongy bone (Sb), bone marrow cells (Bm), and joint cavity (Jc). (B) C-Ab and LPS stimulated DC animal showing moderately enlarged synovial membrane (Sm), hyperplastic synovium (Sh), increased synovial vascularity (Sv), inflammation (In), and Pannus formation (Pn). (C) Treatment of the CAIA mice with DAR showed mildly enlarged Sm, Sh, and cartilage erosion (Ce). (D) Treatment of the CAIA mice with MTX showed mildly enlarged Sm, Sh, increased Sv, and induction of inflammation (In). (E) Total lesion score analysis showed that the treatment of CAIA mice with DAR or MTX showed a significant reduction in the lesion score. Non-parametric Kruskal–Wallis analysis was used to calculate the statistical difference in NC versus DC (p-value ## < 0.01), MTX or DAR treatment versus DC (p-value * < 0.05; ** < 0.01), and comparison between MTX and DAR treatments [p-value ψ > 0.05 (non-significant)].