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. 2019 Aug;47(8):818–831. doi: 10.1124/dmd.119.086462

Fig. 4.

Fig. 4.

Observed vs. predicted plasma concentration-time profiles of acetaminophen in neonates and infants for the mentioned doses. The drug was delivered as an intravenous infusion for 15 minutes in the case of all the figures (A, B, and D-F), except (C) in which the duration of infusion was 50 minutes. Also, separately indicated as bar diagrams is the comparison of mean predicted (without and with proteomics-based ontogeny data) and observed (L20) Cmax (G), and AUC0–6 (H) values for 15 mg/kg acetaminophen administered as intravenous infusion for 15 minutes to neonates and infants. In this case, the average age values for neonates and infants were considered as 14 days and 1 year, respectively, in accordance with US-FDA label (https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022450Orig1s000ClinPharmR.pdf). Abbreviations used in the illustration represent the following literature references: L17 (Zuppa et al., 2011), L18 (Cook et al., 2016), L19 (Allegaert et al., 2013), and L20 (https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022450Orig1s000ClinPharmR.pdf).