TABLE 1.
Hepatic SULT protein abundance data with demographic details.
The number of samples in each category is indicated in parentheses. Median and mean values for SULT1A1 and SULT2A1 are expressed in picomoles per milligram of cytosol protein, whereas those for SULT1B1 and SULT1A3 are expressed in relative value (normalized by the pooled quality control values). Mean adult abundance value was taken as 1 to calculate SF for all the SULTs. Only SNPs with significant association with protein abundance are tabulated here (see also Supplemental Figs. 3 and 4 for SNPs and CNV, respectively.
| Median | Min | Max | Mean | S.D. | %CV | S.E. | SF | Lower 95% CI | Higher 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SULT1A1 | All samples (190) | 387.0 | 27.1 | 1658.0 | 445.2 | 281.1 | 63.1 | 20.4 | NA | 404.9 | 485.4 |
| Neonatal (4) | 99.1 | 57.6 | 126.8 | 95.7 | 28.8 | 30.1 | 14.4 | 0.24 | 49.8 | 141.5 | |
| Infancy (17) | 189.2 | 52.2 | 824.0 | 323.1 | 254.1 | 78.6 | 61.6 | 0.80 | 192.4 | 453.7 | |
| Toddler/early childhood (29) | 610.3 | 113.5 | 1658.0 | 639.2 | 333.4 | 52.2 | 61.9 | 1.57 | 512.4 | 766.1 | |
| Middle childhood (37) | 512.0 | 30.8 | 1046.0 | 506.4 | 283.5 | 56.0 | 46.6 | 1.25 | 411.9 | 601.0 | |
| Adolescence (46) | 338.7 | 27.1 | 1153.0 | 397.7 | 306.3 | 77.0 | 45.2 | 0.98 | 306.7 | 488.7 | |
| Adulthood (57) | 370.9 | 147.6 | 1116.0 | 405.9 | 163.7 | 40.3 | 21.7 | 1.00 | 362.5 | 449.3 | |
| Female (73) | 394.4 | 30.8 | 1240.0 | 450.6 | 258.7 | 57.4 | 30.3 | NA | 390.2 | 510.9 | |
| Male (115) | 376.9 | 27.1 | 1658.0 | 442.8 | 297.6 | 67.2 | 27.8 | NA | 387.8 | 497.8 | |
| African American (29) | 313.2 | 78.6 | 792.3 | 348.7 | 233.9 | 67.1 | 43.4 | NA | 259.7 | 437.6 | |
| Caucasian (120) | 358.7 | 27.1 | 1116.0 | 386.3 | 231.4 | 59.9 | 21.1 | NA | 344.4 | 428.1 | |
| CNV 1 (5) | 219.2 | 121.4 | 376.4 | 245.1 | 108.2 | 44.1 | 48.4 | NA | 110.7 | 379.5 | |
| CNV 2 (82) | 387.0 | 27.1 | 1153.0 | 434.6 | 298.0 | 68.6 | 32.9 | NA | 369.2 | 500.1 | |
| CNV 3 (28) | 577.3 | 72.6 | 1240.0 | 534.4 | 347.6 | 65.0 | 65.7 | NA | 399.6 | 669.1 | |
| CNV 4 (7) | 506.4 | 146.8 | 1658.0 | 573.1 | 536.0 | 93.5 | 202.6 | NA | 77.3 | 1069.0 | |
| SULT1A3 | All samples (190) | 95.7 | 16.9 | 484.7 | 98.1 | 60.7 | 61.9 | 4.4 | NA | 89.4 | 106.8 |
| Neonatal (4) | 40.9 | 30.0 | 81.5 | 48.3 | 23.1 | 47.7 | 11.5 | 0.47 | 11.6 | 85.0 | |
| Infancy (17) | 40.9 | 27.2 | 256.8 | 77.8 | 75.2 | 96.6 | 18.2 | 0.76 | 39.2 | 116.5 | |
| Toddler/early childhood (29) | 109.2 | 25.7 | 330.2 | 116.2 | 74.2 | 63.9 | 13.8 | 1.14 | 87.9 | 144.4 | |
| Middle childhood (37) | 95.5 | 16.9 | 229.0 | 101.5 | 54.8 | 54.0 | 9.0 | 0.99 | 83.3 | 119.8 | |
| Adolescence (46) | 77.2 | 22.6 | 484.7 | 90.5 | 80.8 | 89.2 | 11.9 | 0.88 | 66.5 | 114.5 | |
| Adulthood (57) | 101.6 | 71.5 | 181.2 | 102.3 | 18.2 | 17.7 | 2.4 | 1.00 | 97.5 | 107.1 | |
| Female (75) | 97.8 | 16.9 | 330.2 | 98.2 | 53.0 | 54.0 | 6.1 | NA | 86.0 | 110.4 | |
| Male (113) | 92.9 | 22.6 | 484.7 | 98.3 | 66.0 | 67.1 | 6.2 | NA | 86.0 | 110.6 | |
| African American (28) | 39.3 | 23.6 | 128.5 | 55.6 | 32.8 | 59.0 | 6.2 | NA | 42.9 | 68.4 | |
| Caucasian (119) | 94.6 | 22.6 | 282.8 | 94.6 | 49.8 | 52.6 | 4.6 | NA | 85.5 | 103.6 | |
| SULT1B1 | All samples (191) | 99.9 | 16.7 | 364.7 | 109.1 | 65.6 | 60.1 | 4.7 | NA | 99.7 | 118.4 |
| Neonatal (3) | 19.2 | 16.7 | 28.2 | 21.4 | 6.0 | 28.3 | 3.5 | 0.19 | 6.3 | 36.4 | |
| Infancy (17) | 40.8 | 20.6 | 123.5 | 47.4 | 26.6 | 56.1 | 6.5 | 0.41 | 33.7 | 61.1 | |
| Toddler/early childhood (30) | 110.1 | 26.4 | 338.0 | 128.5 | 75.0 | 58.4 | 13.7 | 1.12 | 100.5 | 156.5 | |
| Middle childhood (37) | 117.8 | 19.4 | 269.1 | 114.9 | 57.2 | 49.8 | 9.4 | 1.00 | 95.8 | 134.0 | |
| Adolescence (47) | 90.9 | 19.8 | 364.7 | 113.2 | 85.2 | 75.3 | 12.4 | 0.99 | 88.2 | 138.3 | |
| Adulthood (57) | 114.7 | 43.9 | 222.2 | 114.6 | 39.5 | 34.4 | 5.2 | 1.00 | 104.1 | 125.1 | |
| Female (75) | 99.5 | 19.2 | 338.0 | 109.7 | 56.5 | 51.5 | 6.5 | NA | 96.7 | 122.7 | |
| Male (114) | 104.6 | 16.7 | 364.7 | 108.9 | 71.6 | 65.8 | 6.7 | NA | 95.6 | 122.2 | |
| African American (28) | 55.3 | 16.7 | 134.2 | 60.0 | 32.4 | 54.0 | 6.1 | NA | 47.4 | 72.5 | |
| Caucasian (121) | 98.7 | 19.2 | 231.3 | 102.2 | 53.6 | 52.5 | 4.9 | NA | 92.6 | 111.9 | |
| rs11249460_C/C (26)# | 122.3 | 68.7 | 222.2 | 127.6 | 41.6 | 32.6 | 8.2 | NA | 110.8 | 144.3 | |
| rs11249460_C/T (29)# | 108.4 | 43.9 | 186.1 | 103.3 | 33.8 | 32.7 | 6.3 | NA | 90.4 | 116.2 | |
| rs11249460_T/T (4)# | 99.7 | 67.6 | 123.9 | 97.7 | 23.2 | 23.8 | 11.6 | NA | 60.7 | 134.7 | |
| SULT2A1 | All samples (183) | 1065.0 | 80.0 | 4085.0 | 1290.0 | 829.0 | 64.3 | 61.3 | NA | 1169.0 | 1411.0 |
| Neonatal (4) | 453.3 | 158.4 | 617.0 | 420.5 | 193.8 | 46.1 | 96.9 | 0.38 | 112.1 | 728.8 | |
| Infancy (17) | 1012.0 | 80.0 | 4085.0 | 1249.0 | 987.3 | 79.0 | 239.5 | 1.11 | 741.3 | 1757.0 | |
| Toddler/early childhood (29) | 1885.0 | 160.4 | 3714.0 | 1832.0 | 1019.0 | 55.6 | 189.2 | 1.63 | 1444.0 | 2220.0 | |
| Middle childhood (37) | 1209.0 | 230.1 | 3949.0 | 1460.0 | 997.0 | 68.3 | 163.9 | 1.30 | 1128.0 | 1793.0 | |
| Adolescence (42) | 882.3 | 128.7 | 2885.0 | 1082.0 | 726.9 | 67.2 | 112.2 | 0.97 | 855.2 | 1308.0 | |
| Adulthood (54) | 1060.0 | 260.9 | 2071.0 | 1121.0 | 359.5 | 32.1 | 48.9 | 1.00 | 1023.0 | 1219.0 | |
| Female (74) | 1035.0 | 160.4 | 3949.0 | 1306.0 | 801.6 | 61.4 | 93.2 | NA | 1120.0 | 1492.0 | |
| Male (107) | 1080.0 | 80.0 | 4085.0 | 1284.0 | 857.7 | 66.8 | 82.9 | NA | 1120.0 | 1449.0 | |
| African American (28) | 853.5 | 80.0 | 3066.0 | 956.6 | 687.2 | 71.8 | 129.9 | NA | 690.1 | 1223.0 | |
| Caucasian (117) | 1036.0 | 95.6 | 4085.0 | 1185.0 | 747.9 | 63.1 | 69.1 | NA | 1048.0 | 1322.0 |
Min, minimum; Max, maximum; S.D., standard deviation; S.E., standard error; SF, scale factor; %CV, percent coefficient variation; 95% CI, 95% confidence interval; NA, not applicable.