Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 30;47(12):e71. doi: 10.1093/nar/gkz224

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 4. — Characterization of the synthetic cathinone-binding affinity of SCA2.1 using ITC. Top panels present raw data showing the heat generated from each titration of (A) (−)-MDPV, (B) (+)-MDPV and (C) (±)-MDPV to SCA2.1, while bottom panels show the integrated heat of each titration after correcting for dilution heat of the titrant. ITC data obtained with (−)-MDPV and (+)-MDPV were fitted using a single-site model, and ITC data obtained with (±)-MDPV were fitted with a modified two-site binding model. All binding parameters are shown in Supplementary Table S4.