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. 2019 Apr 30;47(12):6130–6144. doi: 10.1093/nar/gkz312

Figure 4.

Figure 4.

Zfp217 positively regulates the epitranscriptome of key genes involved in adipogenesis. (A) Overview of different expression genes (DEG) by RNA-seq. (B) Overlapped transcripts of control and Zfp217 knockout in 3T3L1 cells at 0 or 2 d after MDI treatment by RNA-seq. (C) GO analysis of up- and down-regulated genes by RNA seq. The P value for the enrichment of biological process GO-term is shown. (D) Sequence logo representing consensus motif of m6A sites in Zfp217-dependent peaks by MeRIP-seq. (E and F) Metagene profiles of m6A distribution across the transcriptome of 3T3L1 cells at 0 or 2 d after MDI treatment by MeRIP-seq. (G) Overlapped the DEG of RNA-seq with DMR from MDI 0 d of MeRIP -seq respectively to identify the key target genes.