Table 1.
Number of G4-L1-a motifs in the human genome (a = (2,12))
| Number of PQS in hg38 | Number of PQS in local background | Ratio(observed/expected) 10 Kbp bins around PQS | ||||
|---|---|---|---|---|---|---|
| Motif | G3 | G3+ | G3 | G3+ | G3 | G3+ |
| G4-L1 | 18 153 | 39 634 | 487 (±3) | 695 (± 9) | 37 (±0.22) | 57 (±0.76) |
| G4-L1-2 | 51 008 | 79 831 | 2196 (±17) | 2548 (± 19) | 23 (±0.18) | 31 (±0.24) |
| G4-L1-3 | 116 628 | 131 266 | 5612 (±47) | 6053 (± 54) | 21 (±0.18) | 22 (±0.20) |
| G4-L1-4 | 195 501 | 201 984 | 11 300 (±91) | 11 813 (± 74) | 17 (±0.14) | 17 (±0.11) |
| G4-L1-5 | 264 284 | 268 562 | 19 593 (±164) | 20 182 (± 159) | 13 (±0.11) | 13 (±0.10) |
| G4-L1-6 | 331 699 | 334 529 | 30 762 (±176) | 31 389 (± 170) | 11 (±0.06) | 11 (±0.06) |
| G4-L1-7 | 404 347 | 406 531 | 44 983 (±164) | 45 636 (± 199) | 9 (±0.03) | 9 (±0.04) |
| G4-L1-8 | 483 818 | 485 601 | 62 345 (±289) | 63 028 (± 309) | 8 (±0.04) | 8 (±0.04) |
| G4-L1-9 | 563 173 | 564 198 | 82 848 (±334) | 83 593 (± 326) | 7 (±0.03) | 7 (±0.03) |
| G4-L1-10 | 640 520 | 641 386 | 106 862 (±217) | 107 609 (± 173) | 6 (±0.01) | 6 (±0.01) |
| G4-L1-11 | 717 046 | 717 600 | 134 115 (±82) | 134 834 (± 61) | 5 (±0.00) | 5 (±0.00) |
| G4-L1-12 | 796 765 | 797 358 | 164 834 (±21) | 165 584 (± 24) | 5 (±0.00) | 5 (±0.00) |
PQS, putative quadruplex sequences; G3, runs of exactly 3 guanines; G3+, runs of 3 or more guanines. Numbers between parentheses show standard deviation values (from counts in n = 3 independent shuffles).