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. 2019 Apr 17;47(12):6396–6410. doi: 10.1093/nar/gkz274

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Model of gene regulation in trans by the attenuator sRNA rnTrpL in S. meliloti. At TrpL sufficiency, transcription is generally terminated between trpL and trpE(G). The liberated attenuator sRNA rnTrpL binds to trpD and destabilizes the polycistronic mRNA ppiD-trpDC-moaC-moeA. In this way, the trp attenuator posttranscriptionally coordinates the expression of the two trp operons trpE(G) and trpDC in response to Trp availability. In addition, the destabilization of the polycistronic trpDC mRNA by rnTrpL probably affects protein translocation through the outer membrane (ppiD) and MoCo biosynthesis (moaC-moeA). Moreover, the sRNA rnTrpL binds to and destabilizes sinI (27), thus probably linking quorum sensing to Trp availability.