Table 2.
Association between smoking, BMI, physical inactivity, and composite lifestyle variables and overall survival among ovarian cancer cases, Ovarian Cancer Association Consortium1.
Variables | Status |
HR(95%CI)2 | p-value | |||
---|---|---|---|---|---|---|
Died | Alive | |||||
Smoking | ||||||
Never | 2075 | 1746 | 1.00(ref) | |||
Former | 584 | 371 | 1.10 (1.03–1.18) | <0.001 | ||
Current | 1337 | 909 | 1.22 (1.11–1.34) | 0.005 | ||
BMI at the time period preceding diagnosis | ||||||
Underweight | 77 | 63 | 1.04 (0.82–1.30) | 0.75 | ||
Normal weight | 1899 | 1415 | 1.00(ref) | |||
Overweight | 1139 | 872 | 1.02 (0.95–1.10) | 0.58 | ||
Obese | 881 | 676 | 1.16 (1.07–1.25) | <0.001 | ||
Recreational physical inactivity | ||||||
Active | 2895 | 2253 | 1.00(ref) | |||
Inactive | 1100 | 771 | 1.08 (1.01–1.16) | 0.03 | ||
Combined exposure to smoking, overweight/obesity, and physical inactivity | ||||||
Smoking | Overweight/Obese | Inactive | ||||
Never | No | No | 762 | 641 | 1.00(ref) | |
Former | No | No | 487 | 365 | 1.03 (0.92–1.15) | 0.62 |
Current | No | No | 187 | 118 | 1.19 (1.01–1.40) | 0.03 |
Never | Yes | No | 758 | 631 | 1.06 (0.95–1.17) | 0.28 |
Never | No | Yes | 198 | 156 | 1.03 (0.88–1.31) | 0.73 |
Never | Yes | Yes | 321 | 275 | 1.05 (0.92–1.19) | 0.50 |
Former | Yes | No | 491 | 344 | 1.16 (1.03–1.30) | 0.01 |
Former | No | Yes | 143 | 72 | 1.21 (1.01–1.45) | 0.04 |
Former | Yes | Yes | 198 | 122 | 1.35 (1.15–1.59) | <0.001 |
Current | Yes | No | 159 | 110 | 1.28 (1.08–1.52) | 0.005 |
Current | No | Yes | 121 | 62 | 1.26 (1.04–1.54) | 0.02 |
Current | Yes | Yes | 94 | 65 | 1.37 (1.10–1.70) | 0.004 |
Results for the individual models for each factor
Cox proportional hazards model adjusted for age at diagnosis (continuous), stage, and study site