Table 1.
Association between APEX1 gene polymorphisms and neuroblastoma risk.
| Genotype | Cases (N = 469) | Controls (N = 997)a | P b | Crude OR (95% CI) | P | Adjusted OR (95% CI)c | P c |
|---|---|---|---|---|---|---|---|
| rs1130409 (HWE = 0.190) | |||||||
| TT | 175 (37.31) | 340 (34.10) | 1.00 | 1.00 | |||
| TG | 216 (46.06) | 467 (46.84) | 0.90 (0.70-1.15) | 0.389 | 0.90 (0.70-1.15) | 0.390 | |
| GG | 78 (16.63) | 190 (19.06) | 0.80 (0.58-1.10) | 0.167 | 0.79 (0.58-1.09) | 0.159 | |
| Additive | 0.367 | 0.89 (0.77-1.04) | 0.157 | 0.89 (0.76-1.04) | 0.151 | ||
| Dominant | 294 (62.69) | 657 (65.90) | 0.230 | 0.87 (0.69-1.09) | 0.230 | 0.87 (0.69-1.09) | 0.226 |
| Recessive | 391 (83.37) | 807 (80.94) | 0.262 | 0.85 (0.63-1.13) | 0.263 | 0.84 (0.63-1.13) | 0.250 |
| rs1760944 (HWE = 0.231) | |||||||
| TT | 155 (33.05) | 334 (33.50) | 1.00 | 1.00 | |||
| TG | 230 (49.04) | 470 (47.14) | 1.05 (0.82-1.35) | 0.674 | 1.06 (0.83-1.35) | 0.665 | |
| GG | 84 (17.91) | 193 (19.36) | 0.94 (0.68-1.29) | 0.694 | 0.94 (0.68-1.29) | 0.700 | |
| Additive | 0.736 | 0.98 (0.84-1.15) | 0.802 | 0.98 (0.84-1.15) | 0.810 | ||
| Dominant | 314 (66.95) | 663 (66.50) | 0.864 | 1.02 (0.81-1.29) | 0.864 | 1.02 (0.81-1.29) | 0.854 |
| Recessive | 385 (82.09) | 804 (80.64) | 0.509 | 0.91 (0.69-1.21) | 0.509 | 0.91 (0.69-1.21) | 0.511 |
| rs3136817 (HWE = 0.783) | |||||||
| TT | 396 (84.43) | 815 (81.75) | 1.00 | 1.00 | |||
| TC | 67 (14.29) | 172 (17.25) | 0.80 (0.59-1.09) | 0.158 | 0.80 (0.59-1.09) | 0.163 | |
| CC | 6 (1.28) | 10 (1.00) | 1.24 (0.45-3.42) | 0.685 | 1.23 (0.44-3.41) | 0.692 | |
| Additive | 0.329 | 0.87 (0.66-1.14) | 0.300 | 0.87 (0.66-1.14) | 0.306 | ||
| Dominant | 73 (15.57) | 182 (18.25) | 0.205 | 0.83 (0.61-1.11) | 0.206 | 0.83 (0.62-1.11) | 0.211 |
| Recessive | 463 (98.72) | 987 (99.00) | 0.635 | 1.28 (0.46-3.54) | 0.636 | 1.27 (0.46-3.52) | 0.644 |
| Combined effect of protective genotypesd | |||||||
| 0 | 305 (65.03) | 598 (59.98) | 1.00 | 1.00 | |||
| 1-3 | 164 (34.97) | 399 (40.02) | 0.064 | 0.81 (0.64-1.01) | 0.064 | 0.81 (0.64-1.01) | 0.064 |
OR: odds ratio; CI: confidence interval; HWE: Hardy-Weinberg equilibrium. aOne was failed in genotyping. bThe χ 2 test for genotype distributions between neuroblastoma patients and cancer-free controls. cAdjusted for age and gender. dProtective genotypes were rs1130409 GG, rs1760944 GG, and rs3136817 TC/TT.