Table 2.
Functional and pathway enrichment analysis of hub genes.
| Category | Term/Description | Count | P value |
|---|---|---|---|
| GOTERM_BP_FAT | GO:0010243~response to organonitrogen compound | 12 | 1.35E-10 |
| GOTERM_BP_FAT | GO:1901698~response to nitrogen compound | 12 | 5.18E-10 |
| GOTERM_BP_FAT | GO:0009725~response to hormone | 11 | 7.24E-09 |
| GOTERM_BP_FAT | GO:0071495~cellular response to endogenous stimulus | 12 | 1.01E-08 |
| GOTERM_BP_FAT | GO:0009719~response to endogenous stimulus | 13 | 1.08E-08 |
| GOTERM_CC_FAT | GO:0005578~proteinaceous extracellular matrix | 6 | 2.39E-05 |
| GOTERM_CC_FAT | GO:0031012~extracellular matrix | 6 | 2.73E-04 |
| GOTERM_CC_FAT | GO:0098644~complex of collagen trimers | 3 | 3.21E-04 |
| GOTERM_CC_FAT | GO:0044420~extracellular matrix component | 4 | 4.15E-04 |
| GOTERM_CC_FAT | GO:0005667~transcription factor complex | 4 | 5.34E-03 |
| GOTERM_MF_FAT | GO:0000982~transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | 10 | 8.82E-11 |
| GOTERM_MF_FAT | GO:0001228~transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | 9 | 2.20E-09 |
| GOTERM_MF_FAT | GO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | 8 | 7.56E-09 |
| GOTERM_MF_FAT | GO:0000981~RNA polymerase II transcription factor activity, sequence-specific DNA binding | 10 | 2.85E-08 |
| GOTERM_MF_FAT | GO:0044212~transcription regulatory region DNA binding | 9 | 3.61E-06 |
| KEGG_PATHWAY | hsa04512:ECM-receptor interaction | 5 | 6.38E-05 |
| KEGG_PATHWAY | hsa04510:Focal adhesion | 6 | 1.43E-04 |
| KEGG_PATHWAY | hsa04151:PI3K-Akt signaling pathway | 7 | 1.69E-04 |
| KEGG_PATHWAY | hsa05200:Pathways in cancer | 6 | 2.74E-03 |
| KEGG_PATHWAY | hsa04010:MAPK signaling pathway | 5 | 3.64E-03 |
∗ If there were more than 5 terms enriched in this category, the top 5 terms were selected according to P value.