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. Author manuscript; available in PMC: 2019 Jul 9.
Published in final edited form as: Int J Cancer. 2016 Mar 2;139(1):99–111. doi: 10.1002/ijc.30041

Figure 6.

Figure 6.

The PKM2-HuR-p27 pathway controls glioma growth in vivo. (a) Western blot validation of levels of PKM2, p27, HuR and β-actin in cells injected intracranially in panel b. (b) In vivo tumor growth curves of bioluminescently labeled control and PKM2, HuR and p27 modified U87 tumors formed following intracranial implantation of cells. *, p < .05, n = 7. (c) Kaplan-Meyer survival curves for animals (N = 7 for each group) intracranially implanted with control U87+ scramble shRNA, U87 + PKM2 shRNA, U87+PKM2 shRNA+shHuR, U87 + PKM2 shRNA+p27 shRNA, U87 + HuR or U87+p27 cells.