Table 4.
Top 10 pathways of up-and downregulated target genes in IAs and STAs.
| KEGG term | Gene count | Fold enrichment | P value* |
|---|---|---|---|
| Upregulated target genes | |||
| hsa04650: NK cell-mediated cytotoxicity | 33 | 10.1 | 6.6E-11 |
| hsa04660: T cell receptor | 28 | 9.7 | 1.9E-10 |
| hsa04060: Cytokine-cytokine receptor interaction | 48 | 9.0 | 9.8E-10 |
| hsa04621: NOD-like receptor | 35 | 8.5 | 2.9E-09 |
| hsa04217: Necroptosis | 34 | 8.3 | 4.7E-09 |
| hsa05340: Primary immunodeficiency | 37 | 7.1 | 7.5E-08 |
| hsa05168: Chemokine | 35 | 7.6 | 2.3E-08 |
| hsa05167: NF-kappa B signaling pathway | 34 | 8.2 | 5.6E-09 |
| hsa04380: TNF signaling pathway | 26 | 7.0 | 9.0E-08 |
| hsa05340: Cell adhesion molecules | 14 | 7.3 | 4.0E-08 |
| Downregulated target genes | |||
| hsa03010: Ribosome | 21 | 6.0 | 9.2E-07 |
| hsa04520: Adherens junction | 12 | 4.5 | 2.9E-05 |
| hsa04923: Regulation of lipolysis in adipocytes | 10 | 4.2 | 5.4E-05 |
| hsa04360: Axon guidance | 19 | 4.0 | 8.9E-05 |
| hsa05012: Parkinson’s disease | 16 | 3.6 | <0.001 |
| hsa04360: Rap1 signaling pathway | 19 | 4.0 | 8.9E-05 |
| hsa05012: Vascular smooth muscle contraction | 16 | 3.6 | <0.001 |
| hsa05412: Oxidative phosphorylation | 11 | 3.8 | <0.001 |
| hsa05410: cGMP-PKG signaling pathway | 11 | 3.2 | <0.001 |
| hsa00280: Focal adhesion | 8 | 3.1 | <0.001 |
*
IAs vs. STAs.