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. 2019 Jul 9;16:141. doi: 10.1186/s12974-019-1518-0

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Illustration depicting the experiments and protocol applied. Adult female Wistar rats (250 to 300 g) received either a C7-T1 35g clip-compression injury or sham surgery (C7-T1 laminectomy). At 15 mins post-injury, a single bolus of hIgG (0.02, 0.2, 0.4, 1, or 2 g/kg), control buffer, and MPSS (immunosuppressant; 0.03 g/kg) were administered to the injured rats through the tail vein. At 24 hours (h) post-SCI, the spinal cord was collected from the rats for various assays to analyze the local acute inflammatory response. Another group of rats was used for VHRUS, Power Doppler, and immunohistochemistry (IHC) analyses. For protein and histology work, 2 cm of the spinal cord centered at the epicenter was obtained