Table 2.
Odd Ratio and Goodness of Fit for Sequential Models of Mortality Predictions of ADR events
| Variable | Models | ||||
|---|---|---|---|---|---|
| 1 Comorbidities |
2 Comorbidities + Type of Medication |
3 Comorbidities + Type of Medication + Lab Results |
4 Comorbidities + Type of Medication + Lab Results + Total Medication Use |
5 Comorbidities + Type of Medication + Lab Results + Total Medication Use + Renal Replacement Therapy |
|
| a Heart Disease | 0.44 (0.18–1.08) | 0.44 (0.17–1.15) | 0.43 (0.16–1.15) | 0.42 (0.15–1.19) | 0.46 (0.16–1.32) |
| Dyslipidaemia | 0.32 (0.13–0.84) | 0.25 (0.09–0.70) | 0.21 (0.07–0.64) | 0.24 (0.08–0.73) | 0.23 (0.07–0.71) |
| b Electrolyte Disorder | 3.56 (1.19–10.70) | 6.36 (1.92–21.08) | 5.79 (1.70–19.77) | 5.31 (1.49–18.88) | 5.72 (1.57–20.89) |
| c Psychotic Agents | 9.42 (3.04–29.12) | 8.78 (2.68–28.81) | 6.13 (1.77–21.26) | 6.02 (1.76–20.64) | |
| Creatinine Kinase ≥171 U/L | 6.72 (1.70–26.52) | 7.68 (1.75–33.66) | 6.81 (1.49–31.20) | ||
| ≥ 23 No. medications | 4.27 (1.49–12.24) | 4.66 (1.58–13.79) | |||
| Conservative management | 1.59 (0.55–4.66) | ||||
| Hosmer and Lemeshow Test | 0.418 | 0.860 | 0.623 | 0.899 | 0.643 |
| Nagelkerke R Square | 0.127 | 0.267 | 0.329 | 0.393 | 0.399 |
| p value | 0.005 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Abbreviation: GFR, glomerular filtration rate
Data are presented as odd ratios (95% confidence interval) unless otherwise stated
aHeart Disease is defined as presence of vascular or/and heart failure aetiology
bElectrolyte Disorder is defined as presence of hypokalaemia or hyperkalaemia
cPsychrotic Agents is defined as drugs that are classified as psychotropic drugs
dSI conversion: To convert Creatinine kinase to μkat/L, multiply by 58.82