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. 2019 Jul 8;10:205. doi: 10.1186/s13287-019-1304-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Secretome derived from human adipose tissue-derived MSCs activated with TNF-α and IFN-γ displays an enhanced antioxidant and anti-inflammatory activity. a Secretome derived from non-activated MSCs (light blue bar) shows a lower antioxidant capacity, compared with that of activated MSC-derived secretome (blue bar). Antioxidant capacity of MSC-derived secretome was also compared to the antioxidant capacity of human albumin (gray bar) (one-way ANOVA F_2,9 = 92.62, p < 0.0001. Tukey post-hoc: p < 0.001 non-activated MSC secretome versus albumin; p < 0.0001 activated MSC secretome versus albumin and versus non-activated MSC secretome; n = 4 samples per group). b Secretome derived from activated MSCs shows a threefold increase in anti-inflammatory IL-10 and TGF-B1 levels compared with secretome derived from non-activated MSCs (t test; p < 0.05, n = 4 samples per group)