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. 2019 Jul 2;10:1479. doi: 10.3389/fimmu.2019.01479

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Copyright © 2019 Kiernan, Wang, Vanderplow, Cherukuri, Cahill and Watters.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neonatal IH augments anti-inflammatory cytokine gene expression in adult males. (A,B) Adult weights were unchanged in males (A) and females (B) 6 weeks following the last IH exposure. (C,D) Basal gene expression was analyzed in adult male (C) and female (D) microglia 6 weeks post neonatal IH exposure. (E,F) Microglial gene expression was analyzed in male (E) and female (F) neonates exposed to IH followed by LPS challenge. Values represent average fold change +/– SEM *p < 0.05, **p < 0.01, relative to respective Nx control, Two-way ANOVA.