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. 2019 Jul 2;10:1479. doi: 10.3389/fimmu.2019.01479

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Copyright © 2019 Kiernan, Wang, Vanderplow, Cherukuri, Cahill and Watters.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IH sex-specifically affects spontaneous alternation in naïve young adults. Behaviorally naïve adults who were exposed to Nx or IH as neonates were tested in the Y-maze spontaneous alternation task. Nx males (n = 9), IH males (n = 14), Nx females (n = 11) females and IH females (n = 12). The spontaneous alternation index is defined as the number of times a rat made three consecutively correct arm entries/total arm entries minus two. Results represent the average % alternation index in rats from three independent litters +/– SEM, Two-way ANOVA.