Table 3.
Comparison of patients with antibiotics or drainage treatment regarding parameters available on admission
| Antibiotics success (n = 150) | Antibiotics failure (n = 29) | Univariate p | Multivariate OR (95% CI) | Drainage success (n = 18) | Drainage failure (n = 8) | p value | |
|---|---|---|---|---|---|---|---|
| Sex female | 93 (62%) | 20 (69%) | 0.53a | 7 (39%) | 4 (50%) | 0.68c | |
| Age, years, median (IQR) | 61 (50–71) | 60 (53–77) | 0.63b | 60 (53–71) | 55 (35–69) | 0.29b | |
| WBC, ×109/l, median (IQR) | 11.6 (9.3–14.5) | 15.2 (11.2–18.8) | 0.001b | 11.1 (8.6–14.8) | 11. (8.3–15.6) | 0.82b | |
| WBC ≥ 15.0 | 32 (21%) | 15 (52%) | 0.002a | 3.3 (1.3–8.0) | 3 (17%) | 2 (25%) | 0.63c |
| CRP, mg/l, median (IQR) | 123 (82–169) | 181 (92–272) | 0.009b | 126 (115–140) | 122 (31–297) | 0.89b | |
| CRP over ≥175 | 35 (23%) | 15 (52%) | 0.003a | NS | 6 (33%) | 4 (50%) | 0.66c |
| Abscess diameter, mm, median (IQR) | 33 (22–45) | 50 (36–76) | < 0.001b | 59 (49–90) | 67 (54–88) | 0.61b | |
| Abscess diameter ≥ 50 mm | 29 (19%) | 16 (55%) | < 0.001a | 3.7 (1.5–8.9) | 14 (78%) | 7 (89%) | 1c |
| Hemoglobin, g/l, median (IQR) | 131 (123–140) | 126 (113–140) | 0.25b | 123 (115–140) | 121 (114–143) | 0.98b | |
| Anemicd | 32 (21%) | 11 (38%) | 0.06a | NS | 10 (56%) | 4 (50%) | 1c |
| Temperature on admission, °C, median (IQR) | 37.5 (37.1–37.9), n = 146 | 37.3 (36.7–37.8), n = 27 | 0.14b | 37.3 (36.9–37.6), n = 17 | 37.1 (36.4–38.1) | 0.8b | |
| MAP on admission, mmHg, median (IQR) | 99 (92–108), n = 146 | 95 (87–104), n = 27 | 0.07 b | 99 (91–111), n = 17 | 98 (87–113) | 0.93b | |
| Multiple abscesses | 23 (15%) | 3 (10%) | 0.77c | 2 (11%) | 1 (13%) | 1c | |
| Intra-abdominal fluid in the fossa douglas | 20 (13%) | 4 (14%) | 1c | 0 | 1 (13%) | 0.31c | |
| Charlson Comorbidity Index, median (IQR) | 2 (1–3) | 3 (1–5) | 0.08b | NS | 2 (1–5) | 2 (0–4) | 0.5b |
| Corticosteroid medication | 10 (7%) | 7 (24%) | 0.009c | 3.9 (1.2–12.4) | 4 (22%) | 2 (25%) | 1c |
| Any earlier diverticulitis | 39 (26%) | 10 (35%) | 0.37c | 6 (33%) | 5 (63%) | 0.22c | |
| Earlier complicated diverticulitis | 6 (4%) | 3 (10%) | 0.16c | NS | 2 (11%) | 4 (50%) | 0.051c |
| Earlier abdominal surgerye | 54 (36%) | 14 (48%) | 0.22a | 5 (28%) | 1 (13%) | 0.63c | |
| No guarding on admission | 42 (28%) | 12 (41%) | 0.19a | NS | 7 (39%) | 6 (75%) | 0.202c |
| Intra-abdominal or retroperitoneal air in CT (non-pericolic) | 13 (9%) | 6 (21%) | 0.09c | NS | 2 (11%) | 1 (13%) | 1c |
| Pelvic abscess | 33 (22%) | 12 (41%) | 0.04a | NS | 7 (39%) | 4 (50%) | 0.68c |
| Initially treated with antibiotics only | – | – | 4 (22%) | 1 (13%) | 1c |
Patients whose treatment was started with antibiotics alone are also included in the drainage group. Parameters with univariate p < 0.2 were selected for the multivariate logistic regression model. Temperature and MAP were left out of the model due to clinically non-significant differences
OR odds ratio, CI confidence interval, IQR interquartile range, WBC white blood cell count, CRP C-reactive protein, NS not selected in backward stepwise selection (likelihood ratio), CT computer tomography, MAP mean arterial pressure
aχ2 test
bMann-Whitney U test
cFisher’s exact test
dHemoglobin < 117 g/l for females or < 134 g/l for males
eIncluding appendectomy, cholecystectomy, hysterectomy, gastrectomy, and resections of bowel