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. 2019 Jul 2;10:1491. doi: 10.3389/fimmu.2019.01491

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Copyright © 2019 Jia, Gong, Zhao, Yang, Ji, Luan, Zang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ALA on cardiac function, inflammation and autophagy in CLP-induced septic rats. (A) ALA elevated LVSP, LVEDP, +dp/dt, –dp/dt, and heart rate in septic rats. (B) ALA inhibited the expression of the pro-inflammatory factors IL-1β, TNF-α, and iNOS, and (C) and increased the expression of the autophagy-associated proteins LC3, Atg5, Atg7, beclin-1, and decreased the expression of p62, as determined by western blot analysis. 3-MA reversed the effects of ALA on cardiac function and these protein expressions. Data are expressed as the mean ± SD, n = 8. **P < 0.01 vs. sham-operated rats, ^#P < 0.05 vs. CLP-operated rats, ^##P < 0.01 vs. CLP-operated rats, ^†P < 0.05 vs. ALA-treated CLP rats, ^††P < 0.01 vs. ALA-treated CLP rats.